So far there is no known pathogen that has managed to develop a resistance against our disinfectant and process.
Even though good cleaning products and disinfectants are available, Covid 19, and HCAI (healthcare associated infections) such as MRSA, ESBL, VRE, C.diff, Norovirus, Salmonella and E.coli present ongoing problems in healthcare.
The main reason for this is due to biofilm; a protective layer know as an ‘extracellular polymeric matrix’ that’s able to protect bacteria from disinfectants and detergents. They are found on almost any surface and can build up to several microns thick.
Until now, biofilms have been almost impossible to remove, allowing bacterial colonies to thrive. Biofilms have dispersal periods where new bacteria is released to form new colonies and biofilm.
This is why even the best disinfectants are sometimes rendered ineffective.